Hepatitis in association with prolonged 6-mercaptopurine therapy.
نویسندگان
چکیده
منابع مشابه
NUDT15 genetic variants and 6-mercaptopurine intolerance in pediatric acute lymphoblastic leukemia: an updated review
Acute lymphoblastic leukemia (ALL) accounts for nearly 30% of pediatric cancers. The maintenance treatment for ALL comprises daily oral 6-mercaptopurine (6-MP) and weekly methotrexate (MTX). 6-MP is a purine analog that can significantly improve the long-term survival of ALL patients. Despite more than 90% of 5-year survival of childhood ALL in developed countries, treatment interruption due to...
متن کاملبررسی اثر آلفا انترفرون در 16 بیمار مبتلا به هپاتیت مزمن ویروسی
Alpha-interferon therapy has been approved for treatment of chronic hepatitis C and B. Candidates for treatment are patients with well-compensated liver disease and histologic evidences of chronic hepatitis who have demonstrated abnormal aminotransferase levels for more than 6 months. From 30 patients with chronic hepatitis with diseases prolonged more than 6 months, we selected only 16 patient...
متن کاملAssociation between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir
Background: Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. Objective: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion in HBeAg positive CHB responder patients treated with ETV. Methods: Polymerase cha...
متن کاملThe association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia.
BACKGROUND Symptomatic fasting hypoglycemia has been reported as an unusual side effect in patients with acute lymphoblastic leukemia (ALL) on maintenance therapy. We evaluated the relation of the red cell 6-mercaptopurine (6-MP) metabolite 6-methyl-mercaptopurine (6MMP) with hypoglycemia. PROCEDURE We retrospectively reviewed charts of three patients with ALL and symptomatic hypoglycemia whi...
متن کاملProlonged Disease-Free Survival in Dogs With Lymphoma After Total-Body Irradiation and Autologous Marrow Transplantation
Dogs with spontaneous lymphoma were treated with one of three aggressive treatment protocols: (1) combination chemotherapy with cyclophosphamide, L-asparaginase. Oncovin#{174}, and prednisone (CLOP); (2) combination chemotherapy with nitrogen mustard, Oncovin#{174}, prednisone, 1-asparaginase, and 6-mercaptopurine (MOPA-6); or (3) MOPA-6 followed by total-body irradiation (TBI) and autologous m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Blood
دوره 14 1 شماره
صفحات -
تاریخ انتشار 1959